Genotype imputation of Metabochip SNPs using a study-specific reference panel of ~4,000 haplotypes in African Americans from the Women's Health Initiative.

doi:10.1002/gepi.21603

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Genotype imputation of Metabochip SNPs using a study-specific reference panel of ~4,000 haplotypes in African Americans from the Women's Health Initiative.

Genetic epidemiology - 1 Feb 2012

Liu Eric Yi, Buyske Steven, Aragaki Aaron K, Peters Ulrike, Boerwinkle Eric, Carlson Chris, Carty Cara, Crawford Dana C, Haessler Jeff, Hindorff Lucia A, Marchand Loic Le, Manolio Teri A, Matise Tara, Wang Wei, Kooperberg Charles, North Kari E, Li Yun

Abstract excerpt

Genetic imputation has become standard practice in modern genetic studies. However, several important issues have not been adequately addressed including the utility of study-specific reference, performance in admixed populations, and quality for less common (minor allele frequency [MAF] 0.005-0.05) and rare (MAF < 0.005) variants. These issues only recently became addressable with genome-wide association studies...

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Genotype imputation of Metabochip SNPs using a study-specific reference panel of ~4,000 haplotypes in African Americans from the Women's Health Initiative.

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