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Article

HIV-1 Gag co-opts a cellular complex containing DDX6, a helicase that facilitates capsid assembly.

The Journal of cell biology - 6 Aug 2012

Reed Jonathan C, Molter Britta, Geary Clair D, McNevin John, McElrath Julie, Giri Samina, Klein Kevin C, Lingappa Jaisri R

Abstract excerpt

To produce progeny virus, human immunodeficiency virus type I (HIV-1) Gag assembles into capsids that package the viral genome and bud from the infected cell. During assembly of immature capsids, Gag traffics through a pathway of assembly intermediates (AIs) that contain the cellular adenosine triphosphatase ABCE1 (ATP-binding cassette protein E1). In this paper, we showed by coimmunoprecipitation and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Argonaute Proteins
Share to ATP-Binding Cassette Transporters

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Capsid

Share to Chlorocebus aethiops

Share to COS Cells

Share to DEAD-box RNA Helicases

Share to Gene Products, gag

Share to Microscopy, Immunoelectron

Source

Open in PubMed Open full text

Identifiers

PMID: 22851315
DOI: 10.1083/jcb.201111012
PMCID: PMC3413349

Genes

DDX6
ABCE1
AGO2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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