Article
Host ABCE1 is at plasma membrane HIV assembly sites and its dissociation from Gag is linked to subsequent events of virus production.
Traffic (Copenhagen, Denmark) - 1 Mar 2007
Dooher Julia E, Schneider Bobbie L, Reed Jonathan C, Lingappa Jaisri R
Abstract excerpt
In primate cells, assembly of a single HIV-1 capsid involves multimerization of thousands of Gag polypeptides, typically at the plasma membrane. Although studies support a model in which HIV-1 assembly proceeds through complexes containing Gag and the cellular adenosine triphosphatase ABCE1 (also termed HP68 or ribonuclease L inhibitor), whether these complexes constitute true assembly intermediates remains...
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