Article
Genetic and Epigenetic Components of Aspirin-Exacerbated Respiratory Disease.
Immunology and allergy clinics of North America - 1 Nov 2016
Dahlin Amber, Weiss Scott T
Abstract excerpt
Aspirin-exacerbated respiratory disease (AERD) severity and its clinical phenotypes are characterized by genetic variation within pathways for arachidonic acid metabolism, inflammation, and immune responses. Epigenetic effects, including DNA methylation and histone protein modification, contribute to regulation of many genes that contribute to inflammatory states in AERD. The development of noninvasive,...
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