Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Akkermansia muciniphila reverses neuronal atrophy in Negr1 knockout mice with depression-like phenotypes.

Gut microbes - 1 Dec 2025

Hwang Hee-Gon, Park Ji-Woo, Lee Hyo-Jin, Ko Moon Yi, Ka Minhan, Lee Yun Kyung, Choi Jaeyoon, In Su-A, Lee Ye-Eun, Lee Soojin, Kim Min-Soo, Kim Jeong-Yoon

Abstract excerpt

Genetic predispositions can shape the gut microbiome, which in turn modulates host gene expression and impacts host physiology. The complex interplay between host genetics and the gut microbiome likely contributes to the development of neuropsychiatric disorders, yet the mechanisms behind these interactions remain largely unexplored. In this study, we investigated the gut microbiota in Negr1 knockout (KO) mice,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anxiety
Share to Atrophy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Depression

Share to Gastrointestinal Microbiome

Share to Hippocampus

Share to Nerve Tissue Proteins

Share to Neurons

Share to Nucleus Accumbens

Source

Open in PubMed Open full text

Identifiers

PMID: 40388597
DOI: 10.1080/19490976.2025.2508424
PMCID: PMC12091914

Genes

NEGR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Akkermansia muciniphila reverses neuronal atrophy in Negr1 knockout mice with depression-like phenotypes.PMID 40388597Read ↗

A role of the subdiaphragmatic vagus nerve in depression-like phenotypes in mice after fecal microbiota transplantation from Chrna7 knock-out mice with depression-like phenotypes.Semantic proximity Read ↗

Potential of Akkermansia muciniphila and its outer membrane proteins as therapeutic targets for neuropsychological diseasesSemantic proximity Read ↗

Arc1 and the microbiota together modulate growth and metabolic traits in Drosophila.Semantic proximity Read ↗

Comparative analysis of the gut microbiota composition in the Cln1R151X and Cln2R207X mouse models of Batten disease and in three wild-type mouse strains.Semantic proximity Read ↗

A role of gut-microbiota-brain axis via subdiaphragmatic vagus nerve in depression-like phenotypes in Chrna7 knock-out mice.Semantic proximity Read ↗

Colitis-associated intestinal microbiota regulates brain glycine and host behavior in miceSemantic proximity Read ↗

Cognitive and autism-like abnormalities are associated with gut microbiome alterations in a mouse model of Neurofibromatosis type ISemantic proximity Read ↗

Effect of Human Infant Gut Microbiota on Mouse Behavior, Dendritic Complexity, and MyelinationSemantic proximity Read ↗

Elevated NEGR1 in brain induces anxiety or depression-like phenotypes and synaptic dysfunctionSemantic proximity Read ↗

Autism-associated synaptic mutations impact the gut-brain axis in mice.Semantic proximity Read ↗

Innate immune system signaling and CD11b <sup>+</sup> CD11c <sup>+</sup> CD103 <sup>+</sup> cell migration to the brain underlie changes in mouse behavior after microbial colonizationSemantic proximity Read ↗

Vagal Sensing of Altered Gut Microbiota Links to Externalizing BehaviorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.