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Article

MLH1 and XRCC1 polymorphisms in Mexican patients with colorectal cancer.

Genetics and molecular research : GMR - 13 Aug 2012

Muñiz-Mendoza R, Ayala-Madrigal M L, Partida-Pérez M, Peregrina-Sandoval J, Leal-Ugarte E, Macías-Gómez N, Peralta-Leal V, Meza-Espinoza J P, Moreno-Ortiz J M, Ramírez-Ramírez R, Suárez-Villanueva S, Gutiérrez-Angulo M

Abstract excerpt

DNA repair proteins maintain DNA integrity; polymorphisms in genes coding for these proteins can increase susceptibility to colorectal cancer (CRC) development. We analyzed a possible association of MLH1 -93G>A and 655A>G and XRCC1 Arg194Trp and Arg399Gln polymorphisms with CRC in Mexican patients. Genomic DNA samples were obtained from peripheral blood of 108 individuals with CRC (study group) at diagnosis...

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Identifiers

PMID: 22843073
DOI: 10.4238/2012.June.27.6

Genes

MLH1
XRCC1

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