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Article

Trends in the Molecular Epidemiology and Genetic Mechanisms of Transmitted Human Immunodeficiency Virus Type 1 Drug Resistance in a Large US Clinic Population.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 7 Jan 2019

Rhee Soo-Yon, Clutter Dana, Fessel W Jeffrey, Klein Daniel, Slome Sally, Pinsky Benjamin A, Marcus Julia L, Hurley Leo, Silverberg Michael J, Kosakovsky Pond Sergei L, Shafer Robert W

Abstract excerpt

Background: There are few large studies of transmitted drug resistance (TDR) prevalence and the drug resistance mutations (DRMs) responsible for TDR in the United States. Methods: Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) and protease sequences were obtained from 4253 antiretroviral therapy (ART)-naive individuals in a California clinic population from 2003 to 2016. Phylogenetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29846534
DOI: 10.1093/cid/ciy453
PMCID: PMC6321854

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