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Human Parvovirus B19 Nonstructural Protein (NS1) Induces Cell Cycle Arrest at G 1 Phase

12 Feb 2003

Abstract excerpt

Human parvovirus B19 infects predominantly erythroid precursor cells, leading to inhibition of erythropoiesis. This erythroid cell damage is mediated by the viral nonstructural protein 1 (NS1) through an apoptotic mechanism. We previously demonstrated that B19 virus infection induces G(2) arrest in erythroid UT7/Epo-S1 cells; however, the role of NS1 in regulating cell cycle arrest is unknown. In this report, by...

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PMID: 12584315
DOI: 10.1128/jvi.77.5.2915-2921.2003

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