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Human Parvovirus B19 Induces Cell Cycle Arrest at G <sub>2</sub> Phase with Accumulation of Mitotic Cyclins

15 Aug 2001

Abstract excerpt

Human parvovirus B19 infects specifically erythroid progenitor cells, which causes transient aplastic crises and hemolytic anemias. Here, we demonstrate that erythroblastoid UT7/Epo cells infected with B19 virus fall into growth arrest with 4N DNA, indicating G(2)/M arrest. These B19 virus-infected cells displayed accumulation of cyclin A, cyclin B1, and phosphorylated cdc2 and were accompanied by an...

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Identifiers

PMID: 11462027
DOI: 10.1128/jvi.75.16.7555-7563.2001

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