Article
PTX3 genetic variation and dizygotic twinning in the Gambia: could pleiotropy with innate immunity explain common dizygotic twinning in Africa?
Annals of human genetics - 1 Nov 2012
Sirugo Giorgio, Edwards Digna R Velez, Ryckman Kelli K, Bisseye Cyrille, White Marquitta J, Kebbeh Bunja, Morris Gerard A J, Adegbola Richard A, Tacconelli Alessandra, Predazzi Irene M, Novelli Giuseppe, Vannberg Fredrik O, Odunsi Kunle, Page Grier P, Williams Scott M
Abstract excerpt
Dizygotic (DZ) twinning has a genetic component and is common among sub-Saharan Africans; in The Gambia its frequency is up to 3% of live births. Variation in PTX3, encoding Pentraxin 3, a soluble pattern recognition receptor that plays an important role both in innate immunity and in female fertility, has been associated with resistance to Mycobacterium tuberculosis pulmonary disease and to Pseudomonas...
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