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Long non-coding RNA GRASLND enhances chondrogenesis via suppression of the interferon type II signaling pathway

23 Mar 2020

Abstract excerpt

The roles of long noncoding RNAs (lncRNAs) in musculoskeletal development, disease, and regeneration remain poorly understood. Here, we identified the novel lncRNA GRASLND (originally named RNF144A-AS1) as a regulator of mesenchymal stem cell (MSC) chondrogenesis. GRASLND, a primate-specific lncRNA, is upregulated during MSC chondrogenesis and appears to act directly downstream of SOX9, but not TGF-β3. We showed...

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PMID: 32202492
DOI: 10.7554/elife.49558

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