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Article

Silicon-Gold Nanoparticles Affect Wharton's Jelly Phenotype and Secretome during Tri-Lineage Differentiation.

International journal of molecular sciences - 15 Feb 2022

Svirshchevskaya Elena V, Sharonova Nina V, Poltavtseva Rimma A, Konovalova Mariya V, Efimov Anton E, Popov Anton A, Sizova Svetlana V, Solovyeva Daria O, Bogdanov Ivan V, Oleinikov Vladimir A

Abstract excerpt

Multiple studies have demonstrated that various nanoparticles (NPs) stimulate osteogenic differentiation of mesenchymal stem cells (MSCs) and inhibit adipogenic ones. The mechanisms of these effects are not determined. The aim of this paper was to estimate Wharton's Jelly MSCs phenotype and humoral factor production during tri-lineage differentiation per se and in the presence of silicon-gold NPs. Silicon...

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Identifiers

PMID: 35216249
DOI: 10.3390/ijms23042134
PMCID: PMC8874983

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