Genetically Engineered-MSC Therapies for Non-unions, Delayed Unions and Critical-size Bone Defects

Abstract excerpt

The normal bone regeneration process is a complex and coordinated series of events involving different cell types and molecules. However, this process is impaired in critical-size/large bone defects, with non-unions or delayed unions remaining a major clinical problem. Novel strategies are needed to aid the current therapeutic approaches. Mesenchymal stem/stromal cells (MSCs) are able to promote bone...

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