Article
Dissociation of accumulated genetic risk and disease severity in patients with schizophrenia.
Translational psychiatry - 4 Oct 2011
Papiol S, Malzahn D, Kästner A, Sperling S, Begemann M, Stefansson H, Bickeböller H, Nave K-A, Ehrenreich H
Abstract excerpt
Genotype-phenotype correlations of common monogenic diseases revealed that the degree of deviation of mutant genes from wild-type structure and function often predicts disease onset and severity. In complex disorders such as schizophrenia, the overall genetic risk is still often >50% but genotype-phenotype relationships are unclear. Recent genome-wide association studies (GWAS) replicated a risk for several...
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