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Article

OTTO: a new strategy to extract mental disease-relevant combinations of GWAS hits from individuals.

Molecular psychiatry - 1 Feb 2018

Ehrenreich H, Mitjans M, Van der Auwera S, Centeno T P, Begemann M, Grabe H J, Bonn S, Nave K-A

Abstract excerpt

Despite high heritability of schizophrenia, genome-wide association studies (GWAS) have not yet revealed distinct combinations of single-nucleotide polymorphisms (SNPs), relevant for mental disease-related, quantifiable behavioral phenotypes. Here we propose an individual-based model to use genome-wide significant markers for extracting first genetic signatures of such behavioral continua. 'OTTO' (old...

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Identifiers

PMID: 27922606
DOI: 10.1038/mp.2016.208
PMCID: PMC5794905

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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