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Article

Onecut transcription factors act upstream of <i>Isl1</i> to regulate spinal motoneuron diversification

26 Jul 2012

Abstract excerpt

During development, spinal motoneurons (MNs) diversify into a variety of subtypes that are specifically dedicated to the motor control of particular sets of skeletal muscles or visceral organs. MN diversification depends on the coordinated action of several transcriptional regulators including the LIM-HD factor Isl1, which is crucial for MN survival and fate determination. However, how these regulators cooperate...

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PMID: 22833130
DOI: 10.1242/dev.078501

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