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Article

A postmitotic role for Isl-class LIM homeodomain proteins in the assignment of visceral spinal motor neuron identity.

Neuron - 5 Feb 2004

Thaler Joshua P, Koo Sonya J, Kania Artur, Lettieri Karen, Andrews Shane, Cox Christopher, Jessell Thomas M, Pfaff Samuel L

Abstract excerpt

LIM homeobox genes have a prominent role in the regulation of neuronal subtype identity and distinguish motor neuron subclasses in the embryonic spinal cord. We have investigated the role of Isl-class LIM homeodomain proteins in motor neuron diversification using mouse genetic methods. All spinal motor neuron subtypes initially express both Isl1 and Isl2, but Isl2 is rapidly downregulated by visceral motor...

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Identifiers

PMID: 14766174
DOI: 10.1016/s0896-6273(04)00011-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A postmitotic role for Isl-class LIM homeodomain proteins in the assignment of visceral spinal motor neuron identity.PMID 14766174Read ↗

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