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Article

Genetic variability in the endocannabinoid system and 12-week clinical response to citalopram treatment: the role of the CNR1, CNR2 and FAAH genes.

Journal of psychopharmacology (Oxford, England) - 1 Oct 2012

Mitjans Marina, Gastó Cristóbal, Catalán Rosa, Fañanás Lourdes, Arias Bárbara

Abstract excerpt

First line treatment of major depression is based on selective serotonin re-uptake inhibitors (SSRIs) that enhance serotonergic neurotransmission by blocking the serotonin transporter. However, clinical response is a complex phenomenon in which other systems such as the endocannabinoid system could be involved. Given the evidence for the role of the endocannabinoid system in the pathogenesis of depression as well...

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Source

Identifiers

PMID: 22826533
DOI: 10.1177/0269881112454229

Genes

CNR1
CNR2
FAAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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