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Article

Alteration of the regiospecificity of human heme oxygenase-1 by unseating of the heme but not disruption of the distal hydrogen bonding network.

Biochemistry - 10 Jan 2006

Wang Jinling, Evans John P, Ogura Hiroshi, La Mar Gerd N, Ortiz de Montellano Paul R

Abstract excerpt

Heme oxygenase regiospecifically oxidizes heme at the alpha-meso position to give biliverdin IXalpha, CO, and iron. The heme orientation within the active site, which is thought to determine the oxidation regiospecificity, is shown here for the human enzyme (hHO1) to be largely determined by inte...

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Identifiers

PMID: 16388581
DOI: 10.1021/bi051645k
PMCID: PMC2507887

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16388581-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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