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Article

The evolutionary dynamics of HIV-1 quasispecies and the development of immunodeficiency disease.

AIDS (London, England) - 1 Nov 1990

Nowak M A, May R M, Anderson R M

Abstract excerpt

This paper presents a theory to explain the development of immunodeficiency disease after a long and variable incubation period of infection with HIV-1. Two assumptions are central to the theory: (1) mutation via reverse transcription during viral replication can generate viral strains resistant to neutralization by antibodies specific to earlier mutants in a particular host; (2) the virus can kill the...

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PMID: 2282182
DOI: 10.1097/00002030-199011000-00007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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