Article
The evolutionary dynamics of HIV-1 quasispecies and the development of immunodeficiency disease.
AIDS (London, England) - 1 Nov 1990
Nowak M A, May R M, Anderson R M
Abstract excerpt
This paper presents a theory to explain the development of immunodeficiency disease after a long and variable incubation period of infection with HIV-1. Two assumptions are central to the theory: (1) mutation via reverse transcription during viral replication can generate viral strains resistant...
Topics
- Acquired Immunodeficiency Syndrome
- Antigenic Variation
- Biological Evolution
- Genetic Variation
- Giant Cells
- HIV Antibodies
- HIV Antigens
- HIV-1
- Humans
- Models, Biological
- Mutation
- Time Factors
- Vaccination
- Virulence