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Article

Relation between flexibility and positively selected HIV-1 protease mutants against inhibitors.

Proteins - 1 Dec 2012

Braz Antônio S K, Tufanetto Patrícia, Perahia David, Scott Luis P B

Abstract excerpt

The antiretroviral chemotherapy helps to reduce the mortality of HIVs infected patients. However, RNA dependant virus replication has a high mutation rate. Human immunodeficiency virus Type 1 protease plays an essential role in viral replication cycle. This protein is an important target for therapy with viral protein inhibitors. There are few works using normal mode analysis to investigate this problem from the...

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PMID: 22821809
DOI: 10.1002/prot.24151

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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