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Article

Recovery of the wild type atomic flexibility in the HIV-1 protease double mutants.

Journal of molecular graphics & modelling - 1 Jun 2015

De Conto Valderes, Braz Antônio S K, Perahia David, Scott Luis P B

Abstract excerpt

The emergence of drug resistant mutations due to the selective pressure exerted by antiretrovirals, including protease inhibitors (PIs), remains a major problem in the treatment of AIDS. During PIs therapy, the occurrence of primary mutations in the wild type HIV-1 protease reduces both the affinity for the inhibitors and the viral replicative capacity compared to the wild type (WT) protein, but additional...

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Identifiers

PMID: 25948548
DOI: 10.1016/j.jmgm.2015.04.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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