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Article

Recovery of the wild type atomic flexibility in the HIV-1 protease double mutants.

Journal of molecular graphics & modelling - 1 Jun 2015

De Conto Valderes, Braz Antônio S K, Perahia David, Scott Luis P B

Abstract excerpt

The emergence of drug resistant mutations due to the selective pressure exerted by antiretrovirals, including protease inhibitors (PIs), remains a major problem in the treatment of AIDS. During PIs therapy, the occurrence of primary mutations in the wild type HIV-1 protease reduces both the affin...

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Source

Identifiers

PMID: 25948548
DOI: 10.1016/j.jmgm.2015.04.006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25948548-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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