Article
Prediction models for platinum-based chemotherapy response and toxicity in advanced NSCLC patients.
Cancer letters - 10 Jul 2016
Yin Ji-Ye, Li Xi, Li Xiang-Ping, Xiao Ling, Zheng Wei, Chen Juan, Mao Chen-Xue, Fang Chao, Cui Jia-Jia, Guo Cheng-Xian, Zhang Wei, Gao Yang, Zhang Chun-Fang, Chen Zi-Hua, Zhou Hui, Zhou Hong-Hao, Liu Zhao-Qian
Abstract excerpt
In this study, we aimed to establish a platinum-based chemotherapy response and toxicity prediction model in advanced non-small cell lung cancer (NSCLC) patients. 416 single nucleotide polymorphisms (SNPs) in 185 genes were genotyped, and their association with drug response and toxicity were estimated using logistic regression. Nine data mining techniques were employed to establish the prediction model; the...
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