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Article

Proteasome inhibition improves the muscle of laminin α2 chain-deficient mice.

Human molecular genetics - 1 Feb 2011

Carmignac Virginie, Quéré Ronan, Durbeej Madeleine

Abstract excerpt

Muscle atrophy, a significant characteristic of congenital muscular dystrophy with laminin α2 chain deficiency (also known as MDC1A), occurs by a change in the normal balance between protein synthesis and protein degradation. The ubiquitin-proteasome system (UPS) plays a key role in protein degradation in skeletal muscle cells. In order to identify new targets for drug therapy against MDC1A, we have investigated...

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Source

Identifiers

PMID: 21084425
DOI: 10.1093/hmg/ddq499

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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