Article
BAY61-3606 affects the viability of colon cancer cells in a genotype-directed manner.
PloS one - 1 Jan 2012
Lau Ken S, Zhang Tinghu, Kendall Krystle R, Lauffenburger Douglas, Gray Nathanael S, Haigis Kevin M
Abstract excerpt
BACKGROUND: K-RAS mutation poses a particularly difficult problem for cancer therapy. Activating mutations in K-RAS are common in cancers of the lung, pancreas, and colon and are associated with poor response to therapy. As such, targeted therapies that abrogate K-RAS-induced oncogenicity would b...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.