Article
Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletion.
Cancer research - 1 Oct 1995
Sun J, Qian Y, Hamilton A D, Sebti S M
Abstract excerpt
Farnesylation of the oncoprotein Ras is required for its cancer-causing activity. We have designed farnesyltransferase inhibitor (FTI)-276, a tetrapeptide mimetic of the carboxyl terminus of K-Ras4B, as a highly potent and selective inhibitor of Ras farnesylation in vitro and in vivo. FTI-276 blo...
Topics
- 3T3 Cells
- Alkyl and Aryl Transferases
- Animals
- Antineoplastic Agents
- Farnesyltranstransferase
- Female
- Gene Deletion
- Genes, p53
- Genes, ras
- Humans
- Lung Neoplasms
- Mice
- Mice, Nude
- Mutation
- Neoplasm Transplantation
- Oligopeptides
- Transferases
- Transplantation, Heterologous