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Article

Radiosensitizing effects of the prenyltransferase inhibitor AZD3409 against RAS mutated cell lines.

Cancer biology & therapy - 1 Sept 2006

Cengel Keith A, Deutsch Eric, Stephens Trevor C, Voong K Ranh, Kao Gary D, Bernhard Eric J

Abstract excerpt

Mutations at the H-, N- and K-ras loci are among the most frequent genetic alterations in human cancers. In this study, we have investigated the effect of AZD3409, a novel, peptidomimetic prenyltransferase inhibitor (PTI), on the radiosensitivity of cells with mutated ras alleles. AZD3409, develo...

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Identifiers

PMID: 16969121
DOI: 10.4161/cbt.5.9.3172

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16969121-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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