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Article

Global transcriptome analysis in influenza-infected mouse lungs reveals the kinetics of innate and adaptive host immune responses.

PloS one - 1 Jan 2012

Pommerenke Claudia, Wilk Esther, Srivastava Barkha, Schulze Annika, Novoselova Natalia, Geffers Robert, Schughart Klaus

Abstract excerpt

An infection represents a highly dynamic process involving complex biological responses of the host at many levels. To describe such processes at a global level, we recorded gene expression changes in mouse lungs after a non-lethal infection with influenza A virus over a period of 60 days. Global analysis of the large data set identified distinct phases of the host response. The increase in interferon genes and...

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Source

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Identifiers

PMID: 22815957
DOI: 10.1371/journal.pone.0041169
PMCID: PMC3398930

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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