Article
Genetic assessment of the importance of galectin-3 in cancer initiation, progression, and dissemination in mice.
Glycobiology - 1 Jan 2009
Eude-Le Parco Isabelle, Gendronneau Gaëlle, Dang Tien, Delacour Delphine, Thijssen Victor L, Edelmann Winfried, Peuchmaur Michel, Poirier Françoise
Abstract excerpt
The galectin family of beta-galactoside binding lectins is involved in normal and pathological processes. Altered expression of galectin-3 has been described in many cancers, and studies of cancer cell lines have implicated this lectin in various aspects of the tumorigenic cascade. The goal of this report was to directly assess the importance of galectin-3 in tumor biology by introducing the galectin-3 null...
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