Article
A comparison of gene region simulation methods.
PloS one - 1 Jan 2012
Hendricks Audrey E, Dupuis Josée, Gupta Mayetri, Logue Mark W, Lunetta Kathryn L
Abstract excerpt
BACKGROUND: Accurately modeling LD in simulations is essential to correctly evaluate new and existing association methods. At present, there has been minimal research comparing the quality of existing gene region simulation methods to produce LD structures similar to an existing gene region. Here we compare the ability of three approaches to accurately simulate the LD within a gene region: HapSim (2005), Hapgen...
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