Article
Initiation of the 3':5'-AMP-induced protein kinase A Iα regulatory subunit conformational transition. Part I. A202 and A326 are critical residues.
Biochemistry. Biokhimiia - 1 May 2012
Rogacheva O N, Shchegolev B F, Stefanov V E, Zakharov G A, Savvateeva-Popova E V
Abstract excerpt
Protein-ligand docking and molecular dynamics studies have shown that the key event initiated by 3':5'-AMP binding to the A- and B-domains of protein kinase A Iα regulatory subunit is formation of a hydrogen bond between 3':5'-AMP and A202(A326) (the residue in parentheses being from the B-domain). The A202(A326) amide group movement associated with the bond formation leads to reorganization of the phosphate...
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