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Article

Mouse-adapted H9N2 influenza A virus PB2 protein M147L and E627K mutations are critical for high virulence.

PloS one - 1 Jan 2012

Wang Jingjing, Sun Yipeng, Xu Qi, Tan Yuanyuan, Pu Juan, Yang Hanchun, Brown Earl G, Liu Jinhua

Abstract excerpt

H9N2 influenza viruses have been circulating worldwide in multiple avian species and have repeatedly infected humans to cause typical disease. The continued avian-to-human interspecies transmission of H9N2 viruses raises concerns about the possibility of viral adaption with increased virulence for humans. To investigate the genetic basis of H9N2 influenza virus host range and pathogenicity in mammals, we...

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Identifiers

PMID: 22808250
DOI: 10.1371/journal.pone.0040752
PMCID: PMC3393695

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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