Projection regression models for multivariate imaging phenotype.

Abstract excerpt

This paper presents a projection regression model (PRM) to assess the relationship between a multivariate phenotype and a set of covariates, such as a genetic marker, age, and gender. In the existing literature, a standard statistical approach to this problem is to fit a multivariate linear model to the multivariate phenotype and then use Hotelling's T(2) to test hypotheses of interest. An alternative approach...

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