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Article

Targeted Degradation of the Oncogenic Phosphatase SHP2.

Biochemistry - 31 Aug 2021

Vemulapalli Vidyasiri, Donovan Katherine A, Seegar Tom C M, Rogers Julia M, Bae Munhyung, Lumpkin Ryan J, Cao Ruili, Henke Matthew T, Ray Soumya S, Fischer Eric S, Cuny Gregory D, Blacklow Stephen C

Abstract excerpt

SHP2 is a protein tyrosine phosphatase that plays a critical role in the full activation of the Ras-MAPK pathway upon stimulation of receptor tyrosine kinases, which are frequently amplified or mutationally activated in human cancer. In addition, activating mutations in SHP2 result in developmental disorders and hematologic malignancies. Several allosteric inhibitors have been developed for SHP2 and are currently...

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Identifiers

PMID: 34411482
DOI: 10.1021/acs.biochem.1c00377
PMCID: PMC8410664

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