Article

Targeted degradation of the oncogenic phosphatase SHP2

2021-06-02

Abstract excerpt

SHP2 is a protein tyrosine phosphatase that plays a critical role in the full activation of the Ras/MAPK pathway upon stimulation of receptor tyrosine kinases (RTKs), which are frequently amplified or mutationally activated in human cancer. In addition, activating mutations in SHP2 result in developmental disorders and hematologic malignancies. Several allosteric inhibitors have been developed for SHP2 and are cur...

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Literature Corpus work: 5949ae42-99c3-53f6-84e7-e0c674efa2b9
DOI: 10.1101/2021.06.02.446786

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