Article
Familial predisposition to adrenocortical tumors: clinical and biological features and management strategies.
Best practice & research. Clinical endocrinology & metabolism - 1 Jun 2010
Ribeiro Raul C, Pinto Emilia M, Zambetti Gerard P
Abstract excerpt
The incidence of adrenocortical tumors (ACTs) is increased in several familial cancer syndromes resulting from abnormalities in genes that encode transcription factors implicated in cell proliferation, differentiation, senescence, apoptosis, and genomic instability. These include P53, MEN1, APC, and PRKAR1A. Adenomas are the most common ACTs, but adrenocortical carcinomas occur rarely as well. The clinical...
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