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Article

Cord blood-hematopoietic stem cell expansion in 3D fibrin scaffolds with stromal support.

Biomaterials - 1 Oct 2012

Ferreira Mónica S Ventura, Jahnen-Dechent Willi, Labude Norina, Bovi Manfred, Hieronymus Thomas, Zenke Martin, Schneider Rebekka K, Neuss Sabine, Neurs Sabine

Abstract excerpt

Expansion of multipotent, undifferentiated and proliferating cord blood (CB)-hematopoietic stem cells (HSC) in vitro is limited and insufficient. Bone marrow (BM) engineering in vitro allows mimicking the main components of the hematopoietic niche compared to conventional expansion strategies. In this study, four different 3D biomaterial scaffolds (PCL, PLGA, fibrin and collagen) were tested for freshly isolated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22800538
DOI: 10.1016/j.biomaterials.2012.06.029

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MSC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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