Crohn disease: a current perspective on genetics, autophagy and immunity.

doi:10.4161/auto.7.2.13074

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Article

Crohn disease: a current perspective on genetics, autophagy and immunity.

Autophagy - 1 Apr 2011

Stappenbeck Thaddeus S, Rioux John D, Mizoguchi Atsushi, Saitoh Tatsuya, Huett Alan, Darfeuille-Michaud Arlette, Wileman Tom, Mizushima Noboru, Carding Simon, Akira Shizuo, Parkes Miles, Xavier Ramnik J

Abstract excerpt

Crohn disease (CD) is a chronic and debilitating inflammatory condition of the gastrointestinal tract. Prevalence in Western populations is 100-150/100,000 and somewhat higher in Ashkenazi Jews. Peak incidence is in early adult life, although any age can be affected and a majority of affected individuals progress to relapsing and chronic disease. Medical treatments rely significantly on empirical corticosteroid...

Topics

Adrenal Cortex Hormones
Autophagy
Autophagy-Related Proteins
Carrier Proteins
Chronic Disease
Colitis, Ulcerative
Crohn Disease
Dendritic Cells
Genome-Wide Association Study
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Inflammatory Bowel Diseases

Intestines

Paneth Cells

Recurrence

Th17 Cells

Source

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Identifiers

PMID: 20729636
DOI: 10.4161/auto.7.2.13074
PMCID: PMC3842289

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