Article
Crohn disease: a current perspective on genetics, autophagy and immunity.
Autophagy - 1 Apr 2011
Stappenbeck Thaddeus S, Rioux John D, Mizoguchi Atsushi, Saitoh Tatsuya, Huett Alan, Darfeuille-Michaud Arlette, Wileman Tom, Mizushima Noboru, Carding Simon, Akira Shizuo, Parkes Miles, Xavier Ramnik J
Abstract excerpt
Crohn disease (CD) is a chronic and debilitating inflammatory condition of the gastrointestinal tract. Prevalence in Western populations is 100-150/100,000 and somewhat higher in Ashkenazi Jews. Peak incidence is in early adult life, although any age can be affected and a majority of affected individuals progress to relapsing and chronic disease. Medical treatments rely significantly on empirical corticosteroid...
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