Article
The regulation of T-cell recruitment to the human liver during acute liver failure.
Liver international : official journal of the International Association for the Study of the Liver - 1 Jul 2013
Tuncer Ceren, Oo Ye H, Murphy Nick, Adams David H, Lalor Patricia F
Abstract excerpt
BACKGROUND & AIMS: Acute liver failure (ALF) is a rare clinical syndrome with high mortality resulting from hepatocellular necrosis and loss of function. In seronegative hepatitis (SNH), a T-cell-rich infiltrate leads to immune-mediated hepatocyte destruction, whereas in paracetamol poisoning, toxic metabolites induce hepatocyte necrosis, followed by a macrophage-rich, lymphocytic infiltrate that is an important...
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