Article
Association between S21 substitution in the core protein of hepatitis B virus and fulminant hepatitis.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Oct 2012
Inoue Jun, Ueno Yoshiyuki, Kawamura Kaori, Yamamoto Takeshi, Mano Yutaka, Miura Masahito, Kobayashi Tomoo, Niitsuma Hirofumi, Kondo Yasuteru, Kakazu Eiji, Ninomiya Masashi, Kimura Osamu, Obara Noriyuki, Kawagishi Naoki, Kinouchi Yoshitaka, Shimosegawa Tooru
Abstract excerpt
BACKGROUND: The viral factors of hepatitis B virus (HBV), such as genotypes and mutations, were reported to affect the development of fulminant hepatitis B (FHB), but the mechanism is still unclear. OBJECTIVES: To investigate HBV mutations associated with FHB, especially in the subgenotype B1/Bj HBV (HBV/B1), which are known to cause FHB frequently in Japan. STUDY DESIGN: A total of 96 serum samples from acute...
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