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Article

Pancreatic cancer cells enhance the ability of collagen internalization during epithelial-mesenchymal transition.

PloS one - 1 Jan 2012

Ikenaga Naoki, Ohuchida Kenoki, Mizumoto Kazuhiro, Akagawa Shin, Fujiwara Kenji, Eguchi Daiki, Kozono Shingo, Ohtsuka Takao, Takahata Shunichi, Tanaka Masao

Abstract excerpt

BACKGROUND: Extracellular matrix (ECM) remodeling is predominantly mediated by fibroblasts using intracellular and extracellular pathways. Although it is well known that extracellular degradation of the ECM by proteases derived from cancer cells facilitates cellular invasion, the intracellular degradation of ECM components by cancer cells has not been clarified. The aim of this study was to characterize collagen...

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Identifiers

PMID: 22792318
DOI: 10.1371/journal.pone.0040434
PMCID: PMC3390374

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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