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Article

Regulation of fibroblast migration on collagenous matrix by a cell surface peptidase complex.

The Journal of biological chemistry - 9 Aug 2002

Ghersi Giulio, Dong Huan, Goldstein Leslie A, Yeh Yunyun, Hakkinen Lari, Larjava Hannu S, Chen Wen-Tien

Abstract excerpt

The invasion of migratory cells through connective tissues involves metallo- and serine types of cell surface proteases. We show that formation of a novel protease complex, consisting of the membrane-bound prolyl peptidases seprase and dipeptidyl peptidase IV (DPPIV), at invadopodia of migratory fibroblasts is a prerequisite for cell invasion and migration on a collagenous matrix. Seprase and DPPIV form a complex...

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Identifiers

PMID: 12023964
DOI: 10.1074/jbc.M202770200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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