Article
Reverse-zymographic analysis of protease nexin-II/amyloid beta protein precursor of human carcinoma cell lines, with special reference to the grade of differentiation and metastatic phenotype.
International journal of cancer - 3 Jan 1995
Kataoka H, Seguchi K, Iwamura T, Moriyama T, Nabeshima K, Koono M
Abstract excerpt
Trypsin inhibitors in serum-free conditioned media (SFCM) of various human carcinoma cell lines were analyzed by reverse zymography. Most of the cells secreted high-molecular-weight trypsin inhibitors (HMTI) larger than 100 kDa. The cell lines of colorectal carcinoma origin had a tendency to secr...
Topics
- Adenocarcinoma
- Amyloid beta-Protein Precursor
- Base Sequence
- Carcinoma, Squamous Cell
- Carcinoma, Transitional Cell
- Cell Differentiation
- Culture Media, Serum-Free
- Humans
- Molecular Sequence Data
- Neoplasm Metastasis
- Neoplasms
- Pancreatic Neoplasms
- Phenotype
- Serine Proteinase Inhibitors