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Article

Rare variants create synthetic genome-wide associations.

PLoS biology - 26 Jan 2010

Dickson Samuel P, Wang Kai, Krantz Ian, Hakonarson Hakon, Goldstein David B

Abstract excerpt

Genome-wide association studies (GWAS) have now identified at least 2,000 common variants that appear associated with common diseases or related traits (http://www.genome.gov/gwastudies), hundreds of which have been convincingly replicated. It is generally thought that the associated markers reflect the effect of a nearby common (minor allele frequency >0.05) causal site, which is associated with the marker,...

Topics

Anemia, Sickle Cell
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotype
Hearing Loss
Humans
Polymorphism, Single Nucleotide
Probability
Risk Factors

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20126254
DOI: 10.1371/journal.pbio.1000294
PMCID: PMC2811148

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