Article
Polymorphism of Clara cell 10-kD protein gene of sarcoidosis.
American journal of respiratory and critical care medicine - 15 Jan 2004
Ohchi Takashi, Shijubo Noriharu, Kawabata Isao, Ichimiya Shingo, Inomata Shin-ichiro, Yamaguchi Akihiro, Umemori Yoshifumi, Itoh Yoshihisa, Abe Shosaku, Hiraga Yomei, Sato Noriyuki
Abstract excerpt
Clara cell 10-kD protein (CC10) exhibits potent antiinflammatory properties. G38A polymorphism was found in the CC10 gene. We investigated the genetic influence of the allele on the development of sarcoidosis using case control analysis in a Japanese population (265 sarcoidosis cases and 258 control subjects). The A allele frequency in sarcoidosis cases (45.1%) was significantly higher than healthy control...
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