Article
Mannose receptor (MR) engagement by mesothelin GPI anchor polarizes tumor-associated macrophages and is blocked by anti-MR human recombinant antibody.
PloS one - 1 Jan 2011
Dangaj Denarda, Abbott Karen L, Mookerjee Ananda, Zhao Aizhi, Kirby Pamela S, Sandaltzopoulos Raphael, Powell Daniel J, Lamazière Antonin, Siegel Don L, Wolf Claude, Scholler Nathalie
Abstract excerpt
Tumor-infiltrating macrophages respond to microenvironmental signals by developing a tumor-associated phenotype characterized by high expression of mannose receptor (MR, CD206). Antibody cross-linking of CD206 triggers anergy in dendritic cells and CD206 engagement by tumoral mucins activates an immune suppressive phenotype in tumor-associated macrophages (TAMs). Many tumor antigens are heavily glycosylated, such...
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