The DNA binding and accumulation of p53 from breast cancer cell lines and the link with serine 15 phosphorylation.

Abstract excerpt

Stress treatment generally causes the post-translational modification and accumulation of the p53 protein, although the role of these aspects has not been always understood in relation to this protein's tumor suppressor activity. We analyzed these attributes of p53 in eight different breast cancer cell lines, with either wild-type or mutant p53 protein, in response to oxidative stress. We found that the wild-type...

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