Article
Calculating phenotypic similarity between genes using hierarchical structure data based on semantic similarity.
Gene - 10 Apr 2012
Zhang Shanzhen, Chang Zhiqiang, Li Zhenqi, DuanMu Huizi, Li Zihui, Li Kening, Liu Yufeng, Qiu Fujun, Xu Yan
Abstract excerpt
Phenotypic similarity is correlated with a number of measures of gene function, such as relatedness at the level of direct protein-protein interaction. The phenotypic effect of a deleted or mutated gene, which is one part of gene annotation, has caught broad attention. However, there have been few measures to study phenotypic similarity with the data from Human Phenotype Ontology (HPO) database, therefore more...
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