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Article

Mutation and genomic amplification of the PIK3CA proto-oncogene in pituitary adenomas.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas - 1 Sept 2012

Murat C B, Braga P B S, Fortes M A H Z, Bronstein M D, Corrêa-Giannella M L C, Giorgi R R

Abstract excerpt

The tumorigenesis of pituitary adenomas is poorly understood. Mutations of the PIK3CA proto-oncogene, which encodes the p110-α catalytic subunit of PI3K, have been reported in various types of human cancers regarding the role of the gene in cell proliferation and survival through activation of the PI3K/Akt signaling pathway. Only one Chinese study described somatic mutations and amplification of the PIK3CA gene...

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Source

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Identifiers

PMID: 22782554
DOI: 10.1590/s0100-879x2012007500115
PMCID: PMC3854320

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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