Regioselective hydroxylation of trans-resveratrol via inhibition of tyrosinase from Streptomyces avermitilis MA4680.

doi:10.1021/cb300222b

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Article

Regioselective hydroxylation of trans-resveratrol via inhibition of tyrosinase from Streptomyces avermitilis MA4680.

ACS chemical biology - 19 Oct 2012

Lee Nahum, Kim Eun Jung, Kim Byung-Gee

Abstract excerpt

Secreted tyrosinase from melanin-forming Streptomyces avermitilis MA4680 was involved in both ortho-hydroxylation and further oxidation of trans-resveratrol, leading to the formation of melanin. This finding was confirmed by constructing deletion mutants of melC(2) and melD(2) encoding extracellular and intracellular tyrosinase, respectively; the melC2 deletion mutant did not produce piceatannol as well as...

Topics

Catechol Oxidase
Catechols
Hydroxylation
Melanins
Monophenol Monooxygenase
Mutation
Plasmids
Reducing Agents
Resveratrol
Stereoisomerism
Stilbenes
Streptomyces

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Open in PubMed

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PMID: 22769580
DOI: 10.1021/cb300222b

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